Women's Health Weekly
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Breast Cancer
Study data from University Medical Center provide new insights into breast cancer
April 30th, 2009
According to recent research from Hamburg, Germany, "The transcription factor ATF2 is overexpressed in various tumors, but its role in breast cancer is still not understood. In a study of mammary carcinomas, the expression of ATF2 and its phosphorylated active forms was analyzed by Western blot analysis (WB; pThr69/pThr71-ATF2, n=134) and immunohistochemistry (IHC; p-ATF2-Thr6, n=110)." "Results were correlated with histological and clinical data, survival data, expression of ERK1/2 and two matrix metalloproteinases. Patients with high ATF2 expression as detected by WB had a significantly shorter overall survival (p=0.038). This tendency was corroborated by IHC. In...
Source: Women's Health Weekly (2009-04-30)
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