Women's Health Weekly
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Breast Cancer
Studies from Y.S. Lobanova et al have provided new data on breast cancer
May 7th, 2009
According to a study from Russia, "The progression of breast cancer cells to estrogen-independent growth may be accompanied with the paradoxical cell sensitization to estrogen apoptotic action; however, the mechanism of this phenomenon is still unclear. In the present study, we have shown that the sensitization of hormone-resistant breast cancer cells to estrogen apoptotic action is accompanied with the gradual NF-kappa B suppression." "Using the chemical inhibitors of NF-kappa B as well as the dominant-negative NF-kappa B constructs, we have proved the sufficiency of NF-kappa B inhibition for the sensitization of the resistant cells to estrogen apoptosis. Estradiol...
Source: Women's Health Weekly (2009-05-07)
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