Women's Health Weekly
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Breast Cancer
Data on breast cancer published by T. Fujii and colleagues
May 14th, 2009
"Evaluation of: Lee C, Dhillon J, Wang MY et at.: Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res. 68 (21), 8661-8666 (2008). The transcription factor Y-box binding protein (YB)-1 is highly expressed in breast cancer cells and is strongly linked with breast cancer patient prognosis," scientists in Fukuoka, Japan report. "In this paper, siRNA knockdown of YB-1 was used to investigate breast cancer cell proliferation, Six breast cancer cell lines that either overexpress HER-2 or were triple negative demonstrated growth inhibition following YB-1 knockdown. In particular,...
Source: Women's Health Weekly (2009-05-14)
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