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Women's Health Weekly

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Breast Cancer



Research from Malmo University provides new data on breast cancer



May 14th, 2009

According to a study from Malmo, Sweden, "One third of all breast cancers are estrogen receptor alpha (ER alpha) negative, carry a poor overall prognosis, and do not respond well to currently available endocrine therapies. New treatment strategies are therefore required."

"Loss of Wnt-5a has previously been correlated with loss of ER alpha in clinical breast cancer samples, and we sought to investigate this association further. Three breast cancer cell lines (MDA-MB-231, MDA-MB-468, and 4T1) lacking expression of ER alpha and Wnt-5a, and one breast cancer cell line (T47D) expressing both proteins were used in this study. Wnt-5a signaling was generated in ER...


Source: Women's Health Weekly (2009-05-14)

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