Women's Health Weekly
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Breast Cancer
Researchers at University of Manchester release new data on breast cancer
May 14th, 2009
"From a developmental point of view, tumors can be seen as aberrant versions of their tissue of origin. For example, tumors often partially retain differentiation markers of their tissue of origin and there is evidence that they contain cancer stem cells (CSCs) that drive tumorigenesis," scientists writing in the Journal of Mammary Gland Biology and Neoplasia report. "In this review, we summarise current evidence that breast CSCs may partly explain endocrine resistance in breast cancer. In normal breast, the stem cells are known to possess a basal phenotype and to be mainly ER alpha-. If the hierarchy in breast cancer reflects this, the breast CSC may be...
Source: Women's Health Weekly (2009-05-14)
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