Women's Health Weekly
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Breast Cancer
Research from K. Vandewetering and co-researchers yields new findings on breast cancer
May 21st, 2009
According to a study from Netherlands, "The phytoestrogen resveratrol has putative health-promoting effects and is present in several dietary constituents. Resveratrol is metabolized extensively in the gut epithelium, resulting in the formation of hydrophilic glucuronic acid and sulfate conjugates." "These polar resveratrol conjugates need specific transporters to cross the cell membrane. We show here that vectorial transport of some of these metabolites is mediated by multidrug resistance protein 3 (MRP3, ABCC3) and/or breast cancer resistance protein (BCRP, ABCG2) located in the basolateral and apical membranes of enterocytes, respectively. In vitro, MRP3 transports...
Source: Women's Health Weekly (2009-05-21)
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