Women's Health Weekly
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Breast Cancer
Studies from P. Muller et al add new findings in the area of breast cancer
May 21st, 2009
According to recent research from Huddinge, Sweden, "Regulation Of hairy and enhancer of split homologue 1 (HES-1) by estradiol and all-transretinoic acid affects proliferation of human breast cancer cells. Here, we identity and characterize cis-regulatory elements involved in HES 1 regulation." "In the distal 5' promoter of the HES-1 gene, We found a retinoic acid response element and in the distill 3' region, an estrogen receptor alpha(ER)alpha binding site. The ER alpha binding site, composed of an estrogen response element (ERE) and an ERE half-site, is important for both FRY. binding and transcriptional regulation. Chromatin immunoprecipitation assays revealed that...
Source: Women's Health Weekly (2009-05-21)
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