Women's Health Weekly
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Cancer
New cancer study findings have been published by Y. Nadir and colleagues
May 21st, 2009
"Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulphate (HS) side chains of heparan sulphate proteoglycans oil cell Surfaces and the extracellular matrix: activity that is strongly implicated in tumour metastasis and angiogenesis. It has been shown that heparanase overexpression in human leukaemia, glioma and breast carcinoma cells results in a marked increase in tissue factor (TF) levels," scientists in Haifa, Israel report. "In addition, TF was induced by exogenous addition of recombinant heparanase to tumour cells and primary endothelial cells; induction that was mediated by p38 phosphorylation and correlated with enhanced procoagulant...
Source: Women's Health Weekly (2009-05-21)
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