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Women's Health Weekly

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Cancer



New cancer study results reported from National Institutes of Health



May 21st, 2009

According to recent research from the United States, "Mutations in the FANCJ helicase predispose individuals to breast cancer and are genetically linked to the Fanconi anemia (FA) complementation group J.FA is a chromosomal instability disorder characterized by multiple congenital anomalies, progressive bone marrow failure, and high cancer risk. FANCJ has been proposed to function downstream of FANCD2 monoubi-quitination, a critical event in the FA pathway."

"Evidence supports a role for FANCJ in a homologous recombination pathway of double strand break repair. In an effort to understand the molecular functions of FANCJ, we have investigated the ability of purified...


Source: Women's Health Weekly (2009-05-21)

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