Women's Health Weekly
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Cervical Cancer
Recent findings in cervical cancer described by R. Hariharan and colleagues
May 21st, 2009
According to recent research published in the journal Oncology Reports, "Our aim was to carry out mutational analysis of Smad7 exon 4 that codes for the Smad7 MH2 domain in human cervical cancer tissues. This study is warranted since genetic abnormalities of components of the transforming growth factor-beta (TGF-beta)/Smad signaling system have been implicated in a variety of human cancers." "Further, Smad7 is an important member of the Smad family that functions as a negative feedback regulator of TGF-beta responses. By direct sequencing, we screened 60 histopathologically confirmed human cervical carcinomas for mutations in exon 4 of Smad7 that encodes the MH2...
Source: Women's Health Weekly (2009-05-21)
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