Women's Health Weekly
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Graft-Versus-Host Disease
Data on graft-versus-host disease discussed by researchers at Hadassah University
May 21st, 2009
"Pretransplant donor treatment with immunomodulators such as complete Freund's adjuvant (CFA) or oligodeoxynucleotide sequences expressing CpG motifs (CpG), was applied in sublethally irradiated host mice inoculated with murine models of mammary carcinoma (4TI) or B cell leukemia (BCLI). Spleen cells or IL-2 activated splenocytes (lymphokine activated killer [LAK]) derived from donor mice treated with CpG emulsified in incomplete Freund's adjuvant (IFA), (CpG + IFA) did not cause graft-versus-host disease (GVHD), but were not efficient enough to induce a significant graft-versus-tumor (GVT) response against 4TI cells," investigators in Jerusalem, Israel report. "In...
Source: Women's Health Weekly (2009-05-21)
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