Women's Health Weekly
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Breast Cancer
Findings from J.G. Yague and co-authors provide new insights into breast cancer
May 28th, 2009
"The human aromatase gene (CYP19A1) is controlled by multiple promoters that give rise to different aromatase transcripts. Its regulation has been studied in cells from multiple origins, including placenta, bone, adipose tissue, and breast cancer," scientists in Madrid, Spain report. "However, little is known about its regulation in cells from neural origin. We assessed whether vitamin D, dexamethasone, and the glucocorticoid receptor antagonist mifepristone regulate the aromatase gene in human glioma, neuroblastoma, and breast cancer cells. The results show that these compounds enhance the activity of different aromatase promoters in glioma cells, but not in...
Source: Women's Health Weekly (2009-05-28)
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