Women's Health Weekly
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Breast Cancer
New breast cancer study findings have been reported by scientists at University of Medicine and Dentistry of New Jersey
May 28th, 2009
"Estrogen-related receptors (ERR) are orphan members of the nuclear receptor superfamily most closely related to estrogen receptors (ER). Although ER alpha is a successful target for treating breast cancer, there remains an unmet medical need especially for estrogen-independent breast cancer," scientists in the United States report. "Although estradiol is not an ERR ligand, ER and ERR share many commonalities and overlapping signaling pathways. An endogenous ERR ligand has not been identified; however, novel synthetic ERR alpha subtype-specific antagonists have started to emerge. In particular, we recently identified a novel compound,...
Source: Women's Health Weekly (2009-05-28)
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