Women's Health Weekly
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Breast Cancer
Reports from G.Q. Hua et al highlight recent research in breast cancer
May 28th, 2009
According to a study from Case, France, "Overexpression of the ERBB2 gene, linked to genomic and transcriptional amplifications, is a poor prognosis indicator in 25% to 30% of breast cancers. In contrast to some well-documented genomic amplifications, molecular mechanisms leading to ERBB2 transcriptional overexpression remain poorly characterized." "Gene expression analyses of breast cancer have characterized distinct transcriptional signatures allowing a molecular classification of breast carcinoma. Coexpression of the ERBB2 and GATA4 genes was originally observed in tumors. Both genes are essential for cardiovascular development and GATA4 has been proposed to control...
Source: Women's Health Weekly (2009-05-28)
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