Women's Health Weekly
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Breast Cancer
Research reports on breast cancer from University of Tokyo, Medical Department provide new insights
May 28th, 2009
"Estrogen receptor alpha (ER alpha) is a nuclear receptor that functions as a ligand-activated transcription factor. Besides its genomic action in nuclei, ER alpha could exert nongenomic actions at the plasma membrane," scientists in Hongo, Japan report. "To investigate the mechanism underlying the nongenomic action of ER alpha in breast cancer cells, we generated a construct of membrane-targeted ER alpha (memER), an expression vector of ER alpha without the nuclear localizing signal and including instead the membrane-targeting sequence of Src kinase. MemER was stably expressed in human breast cancer MCF-7 cells. Cell migration test and tumorigenic assay in nude mice...
Source: Women's Health Weekly (2009-05-28)
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