Women's Health Weekly
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Breast Cancer
Study findings from F. Andre et al broaden understanding of breast cancer
May 28th, 2009
" Gene-expression arrays have generated molecular predictors of relapse and drug sensitivity in breast cancer. We aimed to identify exons differently expressed in malignant and benign breast lesions and to generate a molecular classifier for breast-cancer diagnosis," investigators in Villejuif, France report. "Methods 165 breast samples were obtained by fine-needle aspiration. Complementary DNA was hybridised on splice array. A nearest centroid prediction rule was developed to classify lesions as malignant or benign on a training set, and its performance was assessed on an independent validation set. A two-way ANOVA model identified probe sets with differential...
Source: Women's Health Weekly (2009-05-28)
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