Women's Health Weekly
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Cancer
Investigators at INSERM target cancer
May 28th, 2009
"Voltage-gated sodium channels (Na-V) are functionally expressed in highly metastatic cancer cells derived from nonexcitable epithelial tissues (breast, prostate, lung, and cervix). MDA-MB-231 breast cancer cells express functional sodium channel complexes, consisting of Na(V)1.5 and associated auxiliary beta-subunits, that are responsible for a sustained inward sodium current at the membrane potential," scientists in Tours, France report. "Although these channels do not regulate cellular multiplication or migration, their inhibition by the specific blocker tetrodotoxin impairs both the extracellular gelatinolytic activity (monitored with DQ-gelatin) and cell...
Source: Women's Health Weekly (2009-05-28)
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