Women's Health Weekly
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Breast Cancer
New findings from University of Verona in the area of breast cancer described
June 4th, 2009
"We evaluated intratumoral heterogeneity of 30 ductal breast carcinomas with HER2/neu amplification, scored by the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) criteria, and 3+ immunoexpression. High-grade (ratio >= 4.0) vs low-grade amplification (ratio >2.2 to <4.0) and chromosome 17 polysomy were also evaluated," scientists in Verona, Italy report. "On whole tissue sections, 20 tumors (67%) showed high-grade and 10 (33%) showed low-grade HER2/neu amplification. Of 20 tumors with high-grade amplification, 14 (700) showed no intratumoral genotypic heterogeneity; 6 (30%) showed at least 1 core with low-grade amplification....
Source: Women's Health Weekly (2009-06-04)
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