Women's Health Weekly
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Breast Cancer
Researchers from University of Toronto report on findings in breast cancer
June 4th, 2009
According to a study from Toronto, Canada, "The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased risk of colon cancer although it may, increase the risk of breast cancer. This polymorphism is associated with changes in intracellular folate cofactors, which may affect DNA methylation and synthesis via altered one-carbon transfer reactions." "We investigated the effect of this mutation on DNA methylation and uracil misincorporation and its interaction with exogenous folate in further modulating these biomarkers of one-carbon transfer reactions in an ill vitro model of the MTHFR 677T mutation in HCT116 colon and...
Source: Women's Health Weekly (2009-06-04)
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