Women's Health Weekly
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Breast Cancer
Studies from University of Pittsburgh have provided new information about breast cancer
June 4th, 2009
"We previously showed that silencing profilin-1 (Pfn1) expression increases breast cancer cell motility, but the underlying mechanisms have not been explored. Herein, we demonstrate that loss of Pfn1 expression leads to slower but more stable lamellipodial protrusion thereby enhancing the net protrusion rate and the overall motility of MDA-MB-231 breast cancer cells," scientists writing in the Journal of Cellular Physiology report. "Interestingly, MDA-MB-231 cells showed dramatic enrichment of VASP at their leading edge when Pfn1 expression was downregulated and this observation was also reproducible in other cell types including human mammary epithelial cells...
Source: Women's Health Weekly (2009-06-04)
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