Women's Health Weekly
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Breast Cancer
Findings from Johns Hopkins University, Medical Department in breast cancer reported
June 11th, 2009
According to recent research from the United States, "Elevated phosphocholine (PC) and total choline (tCho) metabolites are widely established characteristics of most cancer cells, including breast cancer. Effective silencing of choline kinase (chk), the enzyme that converts choline to PC, is associated with reduced tumor growth." "The functional importance and down-regulation of chk using RNA interference has been previously established. Here, we report on the preclinical evaluation of lentiviral vector-mediated down-regulation of chk using short hairpin RNA (shRNA) in established tumors derived from human breast cancer cells. Concentrated lentivirus expressing shRNA...
Source: Women's Health Weekly (2009-06-11)
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