Women's Health Weekly
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Breast Cancer
New breast cancer study findings have been reported from University of Texas
June 11th, 2009
According to recent research from the United States, "Estrogen receptor a (ER) and p53 are critical prognostic indicators in breast cancer. Loss of functional p53 is correlated with poor prognosis, ER negativity, and resistance to antiestrogen treatment." "Previously, we found that p53 genotype was correlated with ER expression and response to tamoxifen in mammary tumors arising in mouse mammary tumor virus-Wnt-l transgenic mice. These results lead us to hypothesize that p:33 may regulate ER expression. To test this, MCF-7 cells were treated with doxorubicin or ionizing radiation, both of which stimulated a 5-fold increase in p53 expression. ER expression was also...
Source: Women's Health Weekly (2009-06-11)
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