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Journal of the National Cancer Institute

JNCI May 26 issue tip sheet

Published in Women's Health Weekly, June 11th, 2009

Effects of MYC Protein and CIP2A in Gastric Cancer

The presence of the protein CIP2A in tumors is associated with early mortality for gastric cancer patients, according to a new study by Ari Ristimaki, M.D., Ph.D., of the Genome-Scale Biology Research program at the University of Helsinki and colleagues.

CIP2A was previously reported to interact and promote the stability of the MYC oncoprotein and to be overexpressed in head and neck and colon cancers, but its role in gastric cancer was unclear.

The researchers discovered that expression of CIP2A was associated with reduced overall survival among gastric cancer patients with...

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