Women's Health Weekly
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Breast Cancer
Research from Stanford University, Medical Department broadens understanding of breast cancer
June 11th, 2009
According to recent research published in the journal Cancer Research, "Subtypes of breast cancer that represent the two major types of epithelial cells in the breast (luminal and basal) carry distinct histopathologic profiles. Breast cancers of the basal-like subtype, which include the majority of hereditary breast cancers due to mutations in the breast cancer susceptibility gene 1 (BRCA1), frequently assume triple-negative status, i.e., they lack expression of estrogen receptor-a and progesterone receptor, and lack overexpression or amplification of the HER2/NEU oncogene." "Defects in DNA damage response pathways result in genome instability and lead to...
Source: Women's Health Weekly (2009-06-11)
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