Women's Health Weekly
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Breast Cancer
Research from T.V. Hansen and co-researchers in the area of breast cancer described
June 11th, 2009
According to a study from Copenhagen, Denmark, "Germ-line mutations in the tumour suppressor proteins BRCA1 and BRCA2 predispose to breast and ovarian cancer. We examined 32 breast and/or ovarian cancer patients from Greenland for mutations in BRCA1 and BRCA2." "Whereas no mutations were identified in 19 families, 13 families exhibited a BRCA1 exon 3 nucleotide 234 T> G mutation, which has not previously been reported in the breast cancer information core (BIC) database. The mutation changes a conserved cysteine 39 to a glycine in the Zn2+ site II of the RING domain, which is essential for BRCA1 ubiquitin ligase activity. Eight of the families had members with...
Source: Women's Health Weekly (2009-06-11)
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