Women's Health Weekly
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Breast Cancer
Studies from W.S. Liu et al further understanding of breast cancer
June 11th, 2009
According to a study from the United States, "Inactivation of tumor suppressor p53 is one of the most frequent events in cancer. Unlike many other cancers, however, p53 gene mutations are infrequent in breast cancers, as about 80% of breast tumors contain wild type p53." "The mechanisms underlying functional inactivation of wild type p53 in breast cancer have remained elusive. Besides, how p53 gets activated in breast tumors subjected to radiation therapy remains unknown. We recently reported that in MCF-7 breast cancer cells, estrogen receptor alpha (ER alpha) directly binds to p53 and represses its function. Furthermore, the ER alpha-p53 interaction was disrupted by...
Source: Women's Health Weekly (2009-06-11)
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