Breast Cancer

Studies in the area of breast cancer reported from University of Pennsylvania, Medical Department

Published in Women's Health Weekly, June 11th, 2009

According to a study from the United States, " The transforming growth factor beta-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-beta, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population."

" To evaluate whether TGFB1 L10P also modifies the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, we undertook a multi-center study of 3,442 BRCA1 and 2,095 BRCA2 mutation carriers. We found no evidence of association between TGFB1 L10P and breast cancer risk in either BRCA1 or...

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Source: Women's Health Weekly (2009-06-11)

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