Women's Health Weekly
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Breast Cancer
Investigators at Hadassah University publish new data on breast cancer
June 18th, 2009
"A germ line single nucleotide polymorphism (SNP) in the first intron of the gene encoding MDM2 at position 309, an important modulator of p53, has been described. BRCA1/2 mutation have been associated with increased rates of breast cancers with mutated P53," scientists in Jerusalem, Israel report. "It was shown that the presence of MDM2 309 SNP correlated with younger cancer onset age in individuals with a p53 mutations. The differential effects of this SNP were also linked to estrogen receptor activation. Here we report on our study of 453 Ashkenazi breast cancer patients of whom 180 were positive for the known Ashkenazi BRCA1/2 mutations Methods: DNA from breast...
Source: Women's Health Weekly (2009-06-18)
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