Women's Health Weekly
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Breast Cancer
Data from University of Texas provide new insights into breast cancer
June 25th, 2009
According to a study from the United States, "Overexpression of the ErbB2 receptor tyrosine kinase is prevalent in similar to 30% of human breast cancers and confers Taxol resistance. Our previous work has shown that ErbB2 inhibits Taxol-induced apoptosis in breast cancer cells by transcriptionally up-regulating p21(Cip1)." "However, the mechanism of ErbB2-mediated p21(Cip1) up-regulation is unclear. Here, we show that ErbB2 up-regulates p21(Cip1) transcription through increased Src activity in ErbB2-overexpressing cells. Src activation further activated signal transducer and activator of transcription 3 (STAT3) that recognizes a SIE binding site on the p21(Cip1)...
Source: Women's Health Weekly (2009-06-25)
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