Women's Health Weekly
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Breast Cancer
Investigators at University of Nottingham publish new data on breast cancer
June 25th, 2009
"Post-translational histone modifications are known to be altered in cancer cells, and loss of selected histone acetylation and methylation marks has recently been shown to predict patient outcome in human carcinoma. Immunohistochemistry was used to detect a series of histone lysine acetylation (H3L9ac, H3K18ac, H4K12ac, and H4K16ac), lysine methylation (H3K4me2 and H4K20me3), and arginine methylation (H4R3me2) marks in a well-characterized series of human breast carcinomas (n = 880)," scientists writing in the journal Cancer Research report. "Tissue staining intensities were assessed using blinded semiquantitative scoring. Validation studies were done using...
Source: Women's Health Weekly (2009-06-25)
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