Women's Health Weekly
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Breast Cancer
Research from R. Seifeddine et al has provided new information about breast cancer
June 25th, 2009
According to recent research from Villejuif, France, "CCAAT/enhancer binding protein-alpha (C/EBP alpha) is involved in the control of cell differentiation and proliferation. It has been previously shown that hypoxia (H) down-regulates C/EBP alpha in breast cancer cells; here the effect of estrogen (E-2) during H on C/EBP alpha in T-47D cell line was examined." "By quantitative RT-PCR the C/EBP alpha mRNA stability was analyzed at 21% O-2 and 1% O-2 under E-2. The H-E-2 combination but not E-2 alone reduced the half-life of the C/EBP alpha mRNA. C/EBP alpha promoter activity studies covering -576 bp do not show any effect of E-2; a significant decrease of C/EBP alpha...
Source: Women's Health Weekly (2009-06-25)
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