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Women's Health Weekly

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Breast Cancer



Studies from A. Bier and co-researchers update current data on breast cancer



June 25th, 2009

According to recent research published in the journal Molecular Cancer Therapeutics, "Connexin43 (Cx43) is often deregulated in breast cancer tissue compared with normal adjacent tissue. Stable reexpression of Cx43 in cancer slows growth and renders the cells more sensitive to cytotoxic chemotherapeutics."

"Pseudogenes are often considered nonfunctional copies of DNA. The Cx43 pseudogene (Psi Cx43) possesses all the features of an expressed gene and is exclusively transcribed in breast cancer cell lines and not in normal cells. Psi Cx43 can be translated in vivo, and its protein exhibits growth-suppressive behavior similar to Cx43. We showed that Psi Cx43 binds...


Source: Women's Health Weekly (2009-06-25)

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