Women's Health Weekly
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Breast Cancer
Study data from Baylor College of Medicine, College of Medicine update understanding of breast cancer
June 25th, 2009
"In breast cancer, steroid receptor coactivator-1 (SRC-1) expression positively correlates with HER2 expression and poor prognosis. In mouse mammary tumor virus-polyoma middle T (PyMT) breast cancer mouse model, SRC-1 strongly promotes mammary tumor metastasis," scientists in the United States report. "However, the molecular targets and mechanisms that mediate the role of SRC-I in metastasis are unknown. In this study, SRC-1 wild-type (WT) and knockout (KO) cell lines were developed from the mammary tumors of WT/PyMT and KO/PyMT mice. WT cells exhibited strong migration and invasion capabilities, reduced E-cadherin and beta-catenin epithelial markers, gained N-cadherin...
Source: Women's Health Weekly (2009-06-25)
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