Women's Health Weekly
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Cancer
New cancer study findings recently were published by V. Evdokimova and co-researchers
July 2nd, 2009
"Increased expression of the transcription/translation regulatory protein Y-box binding protein-1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here we establish that YB-1 levels are elevated in invasive breast cancer cells and correlate with reduced expression of E-cadherin and poor patient survival," scientists in Vancouver, Canada report. "Enforced expression of YB-1 in noninvasive breast epithelial cells induced an epithelial-mesenchymal transition (EMT) accompanied by enhanced metastatic potential and reduced proliferation rates. YB-1 directly activates cap-independent translation of messenger RNAs encoding Snail1 and other...
Source: Women's Health Weekly (2009-07-02)
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