Women's Health Weekly
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Breast Cancer
Findings from University of Edinburgh broaden understanding of breast cancer
July 9th, 2009
According to a study from Scotland, " Endocrine agents, such as letrozole, are established in the treatment of hormone-dependent breast cancer. However, response rates are only 50% to 70% in the neoadjuvant setting and lower in advanced disease." "Thus there is a need to identify novel markers predicting for response and to understand molecular mechanisms of resistance. Patients and Methods Sequential tumor biopsies were taken before and after 10 to 14 days of neoadjuvant treatment with letrozole in patients with estrogen receptor-rich breast cancer. Expression profiles on high-density microarray chips were then related to clinical responses as assessed from tumor...
Source: Women's Health Weekly (2009-07-09)
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