Women's Health Weekly
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Breast Cancer
New breast cancer research has been reported by T. Distelmanmenachem et al
July 9th, 2009
" Three mutations in BRCA1 (185delAG 5382InsC) and BRCA2 (6174delT) can be detected in a substantial proportion of Jewish Ashkenazi breast/ovarian cancer families. Family-specific pathogenic mutations in both genes can be detected in up to 5% of high risk Ashkenazim," scientists in Tel Hashomer, Israel report. "The contribution of major gene rearrangements and seemingly pathogenic missense mutations to inherited breast cancer predisposition has never been systematically evaluated in Ashkenazim. Material and methods High risk, Jewish Ashkenazi women, non-carriers of the predominant Jewish BRCA1/BRCA2 mutations, were genotyped for major gene rearrangements in BRCA1/BRCA2...
Source: Women's Health Weekly (2009-07-09)
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