Women's Health Weekly
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Breast Cancer
New findings from University of Texas in the area of breast cancer described
July 9th, 2009
According to recent research from the United States, "Nearly 30% of women with early-stage breast cancer develop recurrent disease attributed to resistance to systemic therapy. Prevailing models of chemotherapy failure describe three resistant phenotypes: cells with alterations in transmembrane drug transport, increased detoxification and repair pathways, and alterations leading to failure of apoptosis." "Proliferative activity correlates with tumor sensitivity. Cell-cycle status, controlling proliferation, depends on local concentration of oxygen and nutrients. Although physiologic resistance due to diffusion gradients of these substances and drugs is a recognized...
Source: Women's Health Weekly (2009-07-09)
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