Women's Health Weekly
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Breast Cancer
Reports on breast cancer findings from Hanyang University provide new insights
July 9th, 2009
According to a study from Seoul, South Korea, "p27 is a member of the Kip family of cyclin-dependent kinase inhibitors and its overexpression results in cell cycle arrest at G1 and/or apoptosis. In addition to its role as a regulator of cell cycle progression, p27 can also participate in cell motility, especially when it is mislocalized in the cytosol." "To further elucidate the role of p27 in the motility of MDA-MB-231 breast cancer cells. we performed p27 knockdown in MDA-MB-231 cells by RNA interference. Infection of MDA-MB-231 cells with retroviruses harboring p27 short hairpin RNA (shRNA) designed from human p27 cDNA resulted in efficient inhibition of p27...
Source: Women's Health Weekly (2009-07-09)
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