Women's Health Weekly
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Breast Cancer
Research on breast cancer detailed by M. Rubenstein and co-authors
July 9th, 2009
"Previous studies have demonstrated that monospecific antisense oligonucleotides (oligos) directed against mRNA encoding proteins associated with tumor growth, death, and survival are efficacious against breast and prostate tumors. Targeted proteins, associated with different signal transduction pathways, have included transforming growth factor-alpha [TGF-alpha (MR1)], its binding site the epidermal growth factor receptor [EGFR (MR2)] sharing sequence homology to the breast cancer prognostic marker Her-2/neu, an apoptosis inhibiting protein [bcl-2 (MR4)], and the androgen receptor [AR (MR5)]," researchers in the United States report. "In attempts to enhance antisense...
Source: Women's Health Weekly (2009-07-09)
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