Women's Health Weekly
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Breast Cancer
Research on breast cancer reported by scientists at University of California
July 9th, 2009
"Estrogen receptor alpha (ER alpha) and E-cadherin are primary markers of luminal epithelial breast cancer cells with E-cadherin being a main caretaker of the epithelial phenotype. E-cadherin repression is needed for cancer cells to acquire motile and invasive properties, and it is known that in ER-positive breast cancer cells, estrogen down-regulate E-cadherin gene transcription," scientists in the United States report. "We report here that ER alpha is bound to the E-cadherin promoter in both the presence and the complete absence of estrogen, suggesting an unexpected role for unliganded ER alpha in E-cadherin transcription. Indeed, our data reveal that activation by...
Source: Women's Health Weekly (2009-07-09)
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