Women's Health Weekly
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Breast Cancer
Research results from M. Graeser and co-authors update knowledge of breast cancer
July 9th, 2009
According to recent research published in the journal Virchows Archiv, "BRCA1-associated breast cancer frequently presents with estrogen-receptor (ER alpha) and progesterone-receptor (PR) negativity, grade 3, and early onset. In contrast, in BRCA1-deficient mice, ER alpha is highly expressed in early tumorigenesis." "In a retrospective cohort study on 587 breast cancer patients with deleterious BRCA1 mutations, the correlation of ER, PR status, grading, age of onset, and tumor size was investigated. ER alpha and PR expression decreased from 62% in ductal carcinoma in situ (DCIS) to 20% and 16% in pT3, respectively (p value for ER 0.025 and PR 0.035, Fisher's...
Source: Women's Health Weekly (2009-07-09)
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