Breast Cancer

Findings in breast cancer reported from C. Justenhoven and co-researchers

Published in Women's Health Weekly, July 16th, 2009

"Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism of xenobiotics and drugs and contributes to the catabolism of endogenous substrates like estradiol. Genetic variability impacts expression and activity of CYP2C19 and therefore can influence catabolism of estrogens," scientists in Stuttgart, Germany report.

"In the present study we analyzed the association of three polymorphisms of CYP2C19 namely CYP2C19*2 (CYP2C19_681_G > A, rs4244285), CYP2C19*3 (CYP2C19_636_G > A, rs57081121) and CYP2C19*17 (CYP2C19_-806_C > T, rs12248560), with breast cancer susceptibility. We genotyped 1,015 breast cancer cases and 1,021 age-matched, population-based...

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Source: Women's Health Weekly (2009-07-16)

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