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Human Papillomavirus

Recent studies from University of Tartu add new data to human papillomavirus

Published in Women's Health Weekly, July 23rd, 2009

According to a study from Tartu, Estonia, "In HPV-related cancers, the ''high-risk'' human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV replication proteins E1 and E2, which ultimately leads to rearrangements within the locus of the integrated viral DNA."

"The current study indicates that the E1- and E2-dependent DNA replication from the integrated HPV origin follows the ''onion skin''-type replication mode and generates a heterogeneous...

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