Journal of Clinical Investigation
Improving mouse heart function following heart attack
Published in Women's Health Weekly, July 30th, 2009
One approach being developed as a way to improve heart function following heart attack is the injection of heart stem/progenitor cells directly into the heart. Now, a team of researchers, at Tokyo Women's Medical University, Japan, and Chiba University Graduate School of Medicine, Japan, has found that transplanting sheets of clonally expanded heart cells expressing the protein Sca-1 (cells that are heart stem/progenitor cells and that the authors term CPCs) improves heart function after a heart attack in mice.
The team, led by Katsuhisa Matsuura and Issei Komuro, found that CPCs not only formed heart muscle cells but also secreted a soluble molecule (sVCAM-1) that...
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