Human Papillomavirus

Research from T. Senger and co-researchers in the area of human papillomavirus described

Published in Women's Health Weekly, August 13th, 2009

According to recent research from Heidelberg, Germany, "Human papillomavirus (HPV) L1 self-assembles into virus-like particles (VLPs), which are the basis for the two commercially available prophylactic vaccines. For one of them (Cervarix ®) HPV 16 and 18 VLPs are being produced in insect cells using the baculovirus expression system."

"However, due to low yield, production of VLPs remains challenging for certain other PV types. Here we report that employment of a modified baculovirus-based (MultiBac) expression system (Berger, I., Fitzgerald, D. J., and Richmond, T. J. (2004). Baculovirus expression system for heterologous multiprotein complexes. Nat. Biotechnol....

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Source: Women's Health Weekly (2009-08-13)

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