Breast Cancer

New breast cancer study findings recently were published by researchers at Albany Medical College, Medical College

Published in Women's Health Weekly, August 20th, 2009

According to recent research from the United States, "Krupple-like transcription factor 5 (KLF5) is a zinc-finger transcription factor promoting cell survival and tumorigenesis in multiple cancers. A high expression level of KLF5 has been shown to be associated with shorter breast cancer patient survival."

"However, the role of KLF5 and mechanism of KLF5 actions in breast cancer remain unclear. In this study, we found that KLF5 knockdown by small interfering RNA in two breast cell lines, MCF10A and BT20, induces apoptosis. Interestingly, a pro-survival phosphatase, dual specificity mitogen-activated protein kinase phosphatase 1 (MKP-1), is down-regulated by KLF5...

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Source: Women's Health Weekly (2009-08-20)

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