Cancer

Research results from University of California update knowledge of cancer

Published in Women's Health Weekly, August 27th, 2009

According to recent research from the United States, "Estrogens and selective estrogen receptor (ER) modulators such as tamoxifen are known to increase uterine cell proliferation. Mounting evidence suggests that estrogen signaling is mediated not only by ER alpha and ER beta nuclear receptors, but also by GPR30 (GPER), a seven transmembrane (7TM) receptor."

"Here, we report that primary human endometriotic H-38 cells express high levels of GPR30 with no detectable ER alpha or ER beta. Using a novel tamoxifen analogue, STX, which activates GPR30 but not ERs, significant stimulation of the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK)...

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Source: Women's Health Weekly (2009-08-27)

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