Breast Cancer
Data on breast cancer discussed by researchers at University of Isfahan
Published in Women's Health Weekly, September 3rd, 2009
According to recent research from Iran, "p16 (INK4A) is a tumor suppressor encoding the Cdk inhibitor protein, which acts to repress Cdk4/6 and pRb phosphorylation. p16 (INK4A) gene can be inactivated by a variety of events, including promoter hypermethylation. To investigate the methylation status of the p16 (INK4A) gene in Iranian patients with breast carcinoma, promoter methylation was studied by methylation-specific PCR (MSP) and restriction enzyme-related PCR (REP)."
"In addition, p16 (INK4A) promoter was analyzed by PCR-SSCP in order to detection of mutation and single nucleotide polymorphisms. Analysis of 70 patients by MPS and REP showed hypermethylation of p16...
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