Yale University
Researchers identify new brain pathway for regulating weight and bone mass
Published in Women's Health Weekly, October 8th, 2009
Contrary to the prevailing view, the hormone leptin, which is critical for normal food intake and metabolism, appears to regulate bone mass and suppress appetite by acting mainly through serotonin pathways in the brain, according to a recent study published in Cell by Yale School of Medicine researchers and colleagues at Columbia University. This new finding contradicts the view that leptin acts primarily in the hypothalamus.
"Our study challenges the view that the hypothalamus is the critical brain site where leptin acts directly to alter neuronal circuit function to suppress appetite and bone metabolism," said Yale researcher and study co-author Tamas Horvath. "We've...
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