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Georgetown University Medical Center

Gene blamed for immunological disorders shown to protect against breast cancer development

Published in Women's Health Weekly, October 29th, 2009

Researchers at Georgetown University Medical Center (GUMC) are voicing alarm that drugs to treat a wide variety of allergies, asthma and autoimmune diseases now in human clinical trials may errantly spur development of breast tumors.

As the researchers report in the October 15 issue of PLoS ONE, the gene SYK and its protein product, Syk*, are crucial for prevention of breast cancer in the mice and human breast cells they studied. The research is the most definitive yet to demonstrate the beneficial function of Syk as a tumor suppressor, but Syk is better known for its negative role in ramping up activity of the immune system, leading to a cornucopia of immunological...

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